An invisible and mysterious force field descends upon a small fictional town in the United States, trapping residents inside, cut off from the rest of civilization. The trapped townsfolk must discover the secrets and purpose of the "dome" and its origins, while coming to learn more than they ever knew about each other.

Three years after a teenager is accused of lying about being raped, two female detectives from Colorado follow evidence of a similar case, that could reveal the truth.

29-year-old Kimmy Schmidt adjusts to life after her rescue from a doomsday cult in Indiana where she and three other women were held for 15 years. Determined to be seen as something other than a victim and armed only with a positive attitude, Kimmy decides to restart her life by moving to New York City, where she quickly befriends her street-wise landlady, Lillian Kaushtupper, finds a roommate in struggling actor, Titus Andromedon, and gains a job as a nanny for the melancholy and out-of-touch socialite, Jacqueline Voorhees. With their help, Kimmy struggles to adapt to an unfamiliar world and jump-start the adult life that had been taken from her.

In 2033, people near death can be “uploaded” into virtual reality afterlife hotels run by 6 tech firms. Cash-strapped Nora lives in Brooklyn and works customer service for the luxurious “Lakeview” digital afterlife. When L.A. party-boy/coder Nathan’s self-driving car crashes, his high-maintenance girlfriend uploads him permanently into Nora’s VR world.

Smart but wholesome Betty embraces her unique appearance and independent attitude in the cutthroat world of New York fashion. It's amazing how Betty can stay true to herself, no matter how much drama the fashionistas throw her way. With the help of her proud yet far-from-glamorous family from Queens, Betty will continue to have big dreams and deal with any obstacle in her own unique style.

The story follows a small group of people who find themselves in possession of the manuscript sequel of a cult graphic novel called The Utopia Experiments, which is rumoured to have predicted the worst disasters of the last century. This leads them to be targeted by an organisation known as The Network, which they must avoid to survive. Using the manuscript, they must uncover the meaning hidden in its pages before the disasters depicted become reality.

Michael thought his life was perfect until his boyfriend blindsides him by walking out the door after 17 years. Overnight, Michael has to confront two nightmares — losing what he thought was his soulmate and suddenly finding himself a single gay man in his mid-forties in New York City.

Former Syracuse, New York, police detective Carrie Wells has hyperthymesia, a rare medical condition that gives her the ability to visually remember everything. She reluctantly joins the New York City Police Department's Queens homicide unit after her former boyfriend and partner asks for help with solving a case. The move allows her to try to find out the one thing she has been unable to remember, which is what happened the day her sister was murdered.

Follows Kyle Turner, a special agent for the National Parks Service who works to enforce human law in nature’s vast wilderness. The investigation of a brutal death sends Turner on a collision course with the dark secrets within the park and in his own past.

Alma, a 28-year-old living in San Antonio, Texas, finds that she has a new relationship to time after nearly dying in a car accident. As Alma develops new abilities, she pursues answers about her father’s death.